Side effects of cyclosporin depending on the dose and are reduced with a decrease in dose. Kidneys: The most common, especially in the first weeks of treatment – complications associated with increased levels of creatinine and urea in serum. These primobolan enanthate phenomena are associated with functional changes in the kidney, they depend on the dose and decrease at lower doses.
Perhaps the development of anemia, rarely – leukopenia. In rare cases – thrombocytopenia and microangiopathic hemolytic anemia.
Primobolan enanthate – excessive hairiness of the skin, rarely – rash, hair loss, allergic skin reactions, skin redness, itching.
Cardio – vascular system:
Common: hypertension, at least – ischemic heart disease.
The immune system:
There are malignant and lymphoproliferative disorders. In the treatment of psoriasis may be benign lymphoproliferative disorders, as well as B and T cell lymphomas, which may disappear with the abolition of the drug.
The digestive system:
Common: anorexia, nausea, vomiting, abdominal pain, diarrhea, gingival hyperplasia, hepatic dysfunction (accompanied by increased levels of bilirubin and “liver” enzymes in the serum); rarely – pancreatitis.
Rare: muscle cramps, muscle pain, muscle weakness.
The nervous system and sensory organs:
Common: tremor, fatigue, paresthesia – mainly in the first weeks of therapy.
Rare: motor neuropathy, symptoms primobolan enanthate of encephalopathy (convulsions, confusion, disorientation, slowness of reactions, agitation, insomnia, visual disturbances, cortical blindness, coma, paresis, cerebellar ataxia).
Laboratory tests, metabolism:
Common: reversible slight increase in the lipid content in the blood serum, as well as weight gain, hyperglycemia, hyperuricemia, hyperkalemia, hypomagnesemia.
Data on drug overdose is limited. In the presence of appropriate indications (disturbance of consciousness, headache, tachycardia, and in some cases – reversible kidney failure), symptomatic therapy.Tacrolimus is not excreted from the body by hemodialysis and hemoperfusion using activated carbon. Showing nonspecific methods of elimination such as gastric lavage.
Interaction with other drugs:
Cyclosporine in combination with potassium-sparing diuretics can cause hyperkalemia or magnesium deficiency, therefore, necessary to control the levels of potassium and magnesium and potassium to avoid excessive intake of food.
With simultaneous application of Tacrolimus hexane with other immunosuppressive drugs increases the risk of infections, and lymphoproliferative disorders.
The risk of nephrotoxicity with concomitant administration of cyclosporin hexane and drugs such as aminoglycosides (gentamicin and tobramycin), amphotericin B, ciprofloxacin, melphalan, trimethoprim, vancomycin, non-steroidal anti-inflammatory drugs (diclofenac, naproxen).
in simultaneous reception with nifedipine may primobolan enanthate develop damage to the gums (hyperplasia).
in organ transplantation in the case of simultaneous use of fibrates (eg bezafibrate, fenofibrate), sometimes there is a more pronounced and persistent deterioration of renal function.
Drugs that increase the concentration cyclosporine in the blood: the ketoconazole, fluconazole, itraconazole, some macrolide antibiotics (e.g. erythromycin, clarithromycin, josamycin, pozinomitsin and pristinamycin), doxycycline, oral contraceptives, propafenone, methylprednisolone (high dose) metokolopramid, danazol, amiodarone, holievaya acid and its derivatives, and calcium channel blockers (e.g., diltiazem, nicardipine, verapamil, mibefradil).
Drugs that lower the concentration of cyclosporine in the blood: barbiturates, carbamazepine, phenytoin, metamizole, rifampicin, nafcillin, orlistat, octreotide, probucol, troglitazone and sulfadimidine and trimethoprim when administered intravenously, as well as preparations containing St. John’s wort grass.