If you can not avoid the combined use, the careful selection of individual doses of cyclosporine.
At simultaneous application of tacrolimus may develop nephrotoxic effect of cyclosporin and increase the period of its half-life.
Tacrolimus reduces clearance and increases the primobolan side effects toxicity of digoxin, colchicine, lovastatin, and prednisolone.
In connection with the immunosuppressive effect of cyclosporine we can not exclude the development of potentially dangerous atypical reactions after vaccination, so you should avoid the use of live attenuated vaccines. flavonoid substances found in grapefruit juice , affect the cytochrome , and therefore may increase the level of cyclosporine in the blood. Therefore it is not recommended to drink grapefruit juice in the range of 1 hour before administration of the drug.
Cyclosporine hexane can be used by physicians experienced in immunosuppressive therapy and of treatment in patients after organ transplantation. Use primobolan side effects of the drug is possible only in specialized hospitals.
During treatment, the need for continuous monitoring of laboratory parameters, blood pressure values, a condition of the liver and kidneys, as well as the determination of the concentration of lipids in the blood serum (before treatment and after the first month of treatment). Recommended strengthening of antihypertensive therapy for high blood pressure.
Cyclosporine can cause hyperkalemia or magnesium deficiency, therefore, first of all, with severe impaired renal function, it is necessary to monitor the level of potassium and magnesium in the blood plasma, avoid excessive potassium intake of (food, potassium-containing drugs ).
When using cyclosporin together with other immunosuppressive drugs there is a risk of excessive immunosuppression, which may lead to infection and the formation of lymphomas (especially Hodgkin and reticular sarcoma).
When receiving the drug to regular skin examination and histological inspection of suspicious sites.
since cyclosporin can primobolan side effects affect kidney function, during the treatment necessary to conduct at least two measurements of the initial values of creatinine in blood serum. The measurements are repeated on a weekly basis during the month, and then for 3 months – from a two-week intervals. Then, at a stable level of creatinine measurement is performed on a monthly basis. More frequent creatinine monitoring is required when the need to increase the dose of cyclosporine, or while the application of non-steroidal anti-inflammatory drugs. In that case the creatinine level rose by more than 30% of the initial value (normal range), it is necessary to reduce the dose of cyclosporin to 25 – 50%. If the serum creatinine level rose by more than 50%, it is necessary to lower the dose of cyclosporine at least 50%. When endogenous uveitis therapy should be under constant ophthalmic control, as well as determining the level of concentration of cyclosporine in the blood. In nephrotic syndrome: It is necessary to determine the initial values and conduct regular monitoring of serum creatinine. Dose correcting this case, taking into account dynamics values creatinine concentration in blood plasma. In the treatment of systemic control creatinine performed at intervals of 2 weeks during the first 3 months of therapy in the future – 1 time in 1 – 2 months.
In the case of long-term (over 1 year) receiving cyclosporine is recommended kidney biopsy. Patients should not receive cyclosporine with uncontrolled high blood pressure. It is possible primobolan side effects worsening of renal function in elderly patients. In patients with psoriasis skin lesions not typical for psoriasis should be biopsied before treatment. Patients with cancer or precancerous changes in the skin should be treated with medication only after appropriate treatment of such changes in the absence of alternative forms of effective therapy. Avoid prolonged sun exposure. Patients on therapy, Cyclosporin Geksalom should avoid direct exposure to sunlight and ultraviolet radiation or therapy. Prior to treatment, as well as in the first 3 months of therapy necessary to control the levels of uric acid in the blood and urine. . allowed to increase the quantities of “liver” enzymes and bilirubin in the blood of most 2 times the treatment of rheumatoid arthritis for safety and efficacy, control measurements should be carried out the following indicators:
- regular monitoring of creatinine levels in the blood;
- hematology profile (the number of erythrocytes, leukocytes, platelets) prior to treatment and every 4 weeks;
- liver counts: at baseline and every 4 weeks;
- urine analysis before treatment and every 4 weeks;
- measuring a blood pressure value: before treatment and every 2 weeks for 3 months, then – once every 4 weeks;
- potassium levels of blood lipids: before treatment and every 4 weeks.
The medicament comprises about 25.5. % primobolan side effects. When observing the recommended dosage for each receiving cyclosporine (24 capsules of 25 mg, 12 capsules of 50 mg and 6 mg capsules, 100) to the body receives 1.2 g of alcohol. Thus there is a risk to the health of liver diseases, alcoholism, epilepsy, brain injuries, pregnancy and for young children. The effect of other medicines may thus weaken or strengthen.