Hypersensitivity to cyclosporin and to other components of the drug. Pregnancy and feeding: The drug for pregnant women is possible only if the expected benefit justifies the potential risk to the fetus.During primobolan dosage breastfeeding should stop taking the drug, since it is possible the penetration of cyclosporin parent milk.
Dosage and administration:
Dosage in organ transplantation: Adults: In this case, as a rule, tacrolimus administered in conjunction with other immunosuppressive agents. The initial dose is 10 – 14 mg / kg per day, divided into 2 separate reception 12 hours apart. This dose is applied for 1 – 2 weeks after surgery. Thereafter, by conducting control of the level of cyclosporine in the blood, primobolan dosage the dose was gradually reduced to 2 – 6 mg / kg per day, as divided into 2 doses. The therapeutic range of blood levels in the subsequent application is from 100 to 400 ng / ml. Shown In renal transplantation, that the recommended dose at the lower limit, i.e. below 3 – 4 mg / kg and the blood concentration of about 100 ng / mL result in risk of rejection reactions. Some patients month after transplantation, while receiving corticosteroids recommended dose is less than 5 mg / kg.
Bone marrow transplantation:
It is generally recommended short-term combination of cyclosporine and methotrexate. Dose picked individually. Mainly for 1 – 2 days before surgery recommended intravenous cyclosporine at 2.5 – 5 mg / kg per day. As will be possible only oral medication, move to the capsules at a dose of 12.5 mg / kg per day (divided into 2 doses) for 3 – 6 months. Further the dose was gradually reduced to complete expiration treatment.
Therapy of acute graft – versus -. Host
starting dose of 12.5 – 15 mg / kg of cyclosporin per day, divided into 2 doses. After 50 days of starting to lower the dose weekly by 5% to the complete abolition of the drug after 20 weeks.
If the cancel receiving cyclosporine again develops acute reaction should again conduct therapy drug.
When receiving primobolan dosage hexane in organ transplantation, bone marrow and acute graft – versus – host observed transient complaints of gastro – intestinal tract, can be 1/3 of the recommended daily dose administered once intravenously with the infusion solution.
Heavy endogenous uveitis:
The initial dose of cyclosporine is 5 – 10 mg / kg per day divided in 2 doses until remission of inflammation and improvement in visual acuity
In severe cases, you can assign an additional 0.2 – 0.6 mg / kg per day of prednisone or other similar glucocorticosteroid.
during maintenance therapy dose should be reduced slowly until the minimum effective dose is in remission of the disease should not exceed 5 mg / kg / day.
The therapeutic level of cyclosporin blood concentration is from 100 to 150 ng / ml.
There are individual data on the use of cyclosporine in children older than 5 years experience in the use of the drug according to the indications primobolan dosage in children under 5 years are available.