To remove the regression of symptoms is recommended dose of cyclosporin 2.5 mg / kg, divided into 2 doses. If a month no improvement of skin condition can gradually increase the dose to 1 mg / kg to a maximum of 5 mg / kg, divided into two separate reception. At primobolan cycle repeat treatment dose is to be minimally effective.
If at a dose of 5 mg / kg every 6 weeks, no significant improvement occurs, it is necessary to cancel the drug.

Nephrotic syndrome:
For removal of regressive symptoms of nephrotic syndrome is recommended to use a dose of not more than 5 mg / kg for adults and no greater than 6 mg / kg in children older than 1 year, divided into 2 separate reception under normal kidney function. For patients with impaired renal function (creatinine level in blood serum above 200 mmol / l in adults and 140 umol / L in children are contraindications), the initial dose of cyclosporine should not exceed 2.5 mg / kg.
The level of a therapeutically effective concentrations of cyclosporine in the blood is from 60 to 160 ng / ml. Check the level of concentration must first, as far as possible, every day, and then -. Every 2 weeks
during the first 3 months of treatment should regularly monitor the level of serum creatinine (normal renal function – every primobolan cycle 2 weeks, when broken – weekly). With a stable level of creatinine can control this value with an interval of 2 months.
If a patient has severe liver dysfunction should be reduced starting dose of cyclosporine by 25 -. 50%
for patients resistant to glucocorticosteroids nephrotic syndrome, if the effectiveness of cyclosporine is not enough, we recommend the combination of cyclosporine with low doses of corticosteroids.
If after 3 months of treatment with cyclosporine is symptoms of nephrotic syndrome, the drug should be discontinued therapy.

Severe Rheumatoid Arthritis:
The first 6 weeks of therapy recommended dose of cyclosporine 2.5 mg / kg divided into 2 doses. In that case, if the drug is poorly tolerated, the dose can be reduced. Further dosage is determined individually depending on the clinical primobolan cycle course of the disease and tolerability and should be minimally effective. Do not exceed a daily dose of 4 mg / kg. In extreme cases, may increase the dose of cyclosporin to 5 mg / kg.
Cyclosporin may be administered in combination with low-dose corticosteroids and / or with non-steroidal anti-inflammatory drugs.
The treatment up to 12 weeks.

Severe form of atopic dermatitis:
To remove the picture of acute disease, a dose of cyclosporine 2.5 mg / kg, divided into 2 separate reception. If after 2 weeks there is no significant improvement, it is necessary to increase the dose of cyclosporine to a maximum of 5 mg / kg.
In a few extreme cases require the use of an initial dose of cyclosporine 5 mg / kg. When the need to improve the gradual reduction in dose.
The course of treatment duration of 8 weeks may be sufficient to cleanse the skin, but it has been shown that treatment for up to 1 year primobolan cycle, effective and well tolerated, provided the compulsory monitoring of all necessary parameters.

How to use:
The capsules primobolan cycle hexane should be always one and the same time of the day during a meal.
The daily dose should always be divided into 2 separate reception.
The capsules should be taken without chewing, washing down with water.
Do not take the capsules with grapefruit juice.

Hypersensitivity to cyclosporin and to other components of the drug. Pregnancy and feeding: The drug for pregnant women is possible only if the expected benefit justifies the potential risk to the fetus.During primobolan dosage breastfeeding should stop taking the drug, since it is possible the penetration of cyclosporin parent milk.

Dosage and administration:

Dosage in organ transplantation: Adults: In this case, as a rule, tacrolimus administered in conjunction with other immunosuppressive agents. The initial dose is 10 – 14 mg / kg per day, divided into 2 separate reception 12 hours apart. This dose is applied for 1 – 2 weeks after surgery. Thereafter, by conducting control of the level of cyclosporine in the blood, primobolan dosage the dose was gradually reduced to 2 – 6 mg / kg per day, as divided into 2 doses. The therapeutic range of blood levels in the subsequent application is from 100 to 400 ng / ml. Shown In renal transplantation, that the recommended dose at the lower limit, i.e. below 3 – 4 mg / kg and the blood concentration of about 100 ng / mL result in risk of rejection reactions. Some patients month after transplantation, while receiving corticosteroids recommended dose is less than 5 mg / kg.

Bone marrow transplantation: It is generally recommended short-term combination of cyclosporine and methotrexate. Dose picked individually. Mainly for 1 – 2 days before surgery recommended intravenous cyclosporine at 2.5 – 5 mg / kg per day. As will be possible only oral medication, move to the capsules at a dose of 12.5 mg / kg per day (divided into 2 doses) for 3 – 6 months. Further the dose was gradually reduced to complete expiration treatment.

Therapy of acute graft – versus -. Host starting dose of 12.5 – 15 mg / kg of cyclosporin per day, divided into 2 doses. After 50 days of starting to lower the dose weekly by 5% to the complete abolition of the drug after 20 weeks. If the cancel receiving cyclosporine again develops acute reaction should again conduct therapy drug. When receiving primobolan dosage hexane in organ transplantation, bone marrow and acute graft – versus – host observed transient complaints of gastro – intestinal tract, can be 1/3 of the recommended daily dose administered nolvadex once intravenously with the infusion solution.

Heavy endogenous uveitis: The initial dose of cyclosporine is 5 – 10 mg / kg per day divided in 2 doses until remission of inflammation and improvement in visual acuity In severe cases, you can assign an additional 0.2 – 0.6 mg / kg per day of prednisone or other similar glucocorticosteroid. during maintenance therapy dose should be reduced slowly until the minimum effective dose is in remission of the disease should not exceed 5 mg / kg / day. The therapeutic level of cyclosporin blood concentration is from 100 to 150 ng / ml. There are individual data on the use of cyclosporine in children older than 5 years experience in the use of the drug according to the indications primobolan dosage in children under 5 years are available.

Upon receiving Cyclosporine hexane stable absorption observed and almost no influence food intake, which ensures low variability expressed pharmacokinetics and effect relationship between the drug and the highest dose. Absorption: After primo steroid oral administration, the maximum concentration of cyclosporine in the blood plasma is achieved in the time interval 95.0 . ± 42,1 minutes distribution: Cyclosporine is primarily distributed in the bloodstream to the magnitude steroids types of the apparent volume of distribution of 3 – 5 l / kg. The plasma is determined by 33 to 47%, in granulocytes – from 5 to 12% in the lymphocytes – 4 to 9% of the erythrocytes and – from 41 to 58% of the injected drug. Plasma protein binding is approximately 90%.

Metabolism: The biotransformation process produces up to 15 metabolites.Major metabolic pathways are mono- and dihydroxylation t bol steroid in different parts of the molecule. Active metabolites of either one does not exceed by more than 10% of the activity of “parent” substance.Excretion: The primo steroid elimination of the organism occurs mainly in the bile, only about 6% of the administered dose excreted in urine as metabolites, and approximately 0.1% – in the form of unchanged substance.Half-life values are significant fluctuations and make up about 6.3 hours in healthy volunteers, approximately 20.4 hours in patients with severe liver diseases and an average 11 hours (from 2 to 25 hours) in renal transplantation. The magnitude of clearance of cyclosporine in children is about 2 times higher than in adults. Capsules and solution for internal use bioequivalent.

Indications for use:

Transplantation:

  • Immune suppression and prevention of transplant rejection tamoxifen side effects bodybuilding after kidney, liver, heart, combined heart-lung transplant, lung, or pancreas.
  • Prevention of graft rejection after bone marrow transplantation.
  • Prevention and treatment primo steroid of graft – versus – host.

Other diseases:

  • Endogenous uveitis (after exclusion of infectious etiology): active, sight-threatening uveitis middle or rear portion of the eye; Behçet uveitis with recurrent attacks of inflammation affecting the retina.
  • Severe psoriasis is usually in cases of resistance to prior treatment.
  • Nephrotic syndrome, dependent on corticosteroids and resistant to them (impaired renal function with a pronounced loss of protein) caused by disorders of the vascular glomerulus (diseases such as minimal change nephropathy, focal and segmental glomerulonephritis).
  • Severe forms of rheumatoid primo steroid arthritis of the active current (in those cases where the classical slow-acting antirheumatic drugs are ineffective npp cycle, or their application is impossible).
  • Severe form of atopic dermatitis when systemic therapy is shown.

Overdosing occurs when cycloserine plasma concentrations of 25-30 mg / ml as a result of receiving high doses of cycloserine and / or renal clearance violations. Acute poisoning can occur with ingestion of more than 1 g / day. Symptoms of chronic intoxication during chronic administration in a dose of 500 mg / day: headache, dizziness, confusion, irritability, paresthesia, psychosis, dysarthria, paresis, seizures, coma. Treatment: symptomatic, activated charcoal, antiepileptics primobolan. To prevent neurotoxic effects of pyridoxine is administered at a dose of 200-300 mg / day, anticonvulsants and sedative drugs.

Interaction with other drugs
increases the rate of excretion by the kidneys of pyridoxine (can cause anemia and peripheral neuritis, require an increase in dose pyridoxine). Ethanol increases the risk of seizures, especially in people who suffer from chronic alcoholism.
Ethionamide increases the risk of side effects from the central nervous system, especially of seizures.
Isoniazid increases the incidence of dizziness, sleepiness.

Special instructions
Before starting therapy should be allocated primobolan cycloserine cultures of microorganisms and to determine the sensitivity of the strains to the drug. In the case of  infection is necessary to determine the strain sensitivity to other anti-TB drugs.
Cycloserine treatment should be abolished or should reduce the dose if the patient has developed allergic dermatitis or symptoms of central nervous system, namely: headache, dizziness, drowsiness, confusion, tremors, peripheral paresis, dysarthria, seizures and psychosis. In view of the low therapeutic index of cycloserine danger of seizures is increased in patients with chronic alcoholism.
Poisoning usually occurs at concentrations of drug in the blood of more than 30 mg / l, which may be the result of an overdose or impaired renal clearance. Before the drug should be controlled hematologic, renal function (blood concentration of creatinine and BUN) concentration of drug in the blood and liver function.
In patients with reduced renal function, receiving a daily dose of 500 mg, and in which presumably show signs and symptoms overdose, drug levels in the blood must be controlled at least once a week. The dose must be adjusted so as to maintain the drug level in the blood is below primobolan. For prevention of symptoms of central nervous system, in particular, convulsions or tremors excitation state may use anticonvulsant or sedative drugs. Patients receiving 500 mg of cycloserine per day, must be under the direct supervision of a physician because of the possible development of similar symptoms. Prevent or reduce the toxic effect of cycloserine can assigning during treatment glutamic acid, 500 mg of 3 – 4 times daily (before food), and the daily / m administration of sodium salt  (1 ml of 1% solution), and pyridoxine dose 200-300 mg / day. For the prevention of adverse effects of neurotoxic prescribed psychotropic medication benzodiazepine diazepam (5 mg) or Phenazepamum (1 mg) overnight and piracetam 800 mg 2 times a day. In some cases, the use of cycloserine can cause the development of vitamin B 12 and / or folic acid megaloblastic and sideroblastic anemia. In case primobolan of anemia during treatment is necessary to conduct an appropriate examination and treatment of the patient.
It should limit the mental stress of patients and prevent possible overheating of the factors (bareheaded sun exposure, hot shower). With the rapid development of resistance is recommended that its combination with other anti-TB drugs in monotherapy cycloserine. Influence receiving cycloserine on driving ability and use of machinery is not established.